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向文胜
男,1968年生人
博士,教授,博士生导师,黑龙江省杰出青年基金获得者,教育部新世纪优秀人才,“龙江学者”特聘教授
联系电话:0451-55190413(O)
传真电话:0451-55190413
电子邮箱:xiagwensheng@yahoo.com.cn
 教育进修
博士后,浙江大学化学系,2003-2005
博士后,中国科学院过程工程所,2001-2003
博士,中国农业大学,1997-2001
硕士,东北农业大学,1989-1992
学士,中南民族大学,1985-1989
 工作经历
2008 - present: Excellent Talents in University, China
2007 - present: Longjiang Scholar Professor
2003 - present: Professor,
2001 - 2003: Associate professor,
2001 - 2003: Postdoctoral fellow,
1996 - 2000: Lecturer,
1993 - 1995: Assistant,
 主讲课程
主讲本科生课程《工业微生物》,主讲硕士研究生课程《仪器分析》、《生物化工研究班讨论》课程。
 学生培养
招收培养硕士研究生58名、博士生31名,指导博士后4名。毕业生中大部分就业于国内知名大学和科研院所,其中13名赴国外深造或工作。1998年被遴选为博士生导师,2000年以来,连续被评为东北农业大学优秀博士生导师,省第三届和第四届优秀研究生学位论文指导教师,黑龙江省研究生优秀导师等。
 研究方向
Current research interests are about isolating and screening of antibiotic-generating strain, secondary metabolite biosynthesis in microorganisms, gene cloning and expression, enzyme reaction mechanisms, metabolic pathway engineering, and natural product drug discovery and development.
 研究课题
(1) 国家科技支撑计划重点项目——新型抗寄生虫原料药的研制与应用,2007-2010
(2 ) 国家科技支撑计划重点项目子项目——抗寄生虫类药物筛选新技术,2007-2010
(3) 教育部新世纪优秀人才计划——农用抗生素米尔贝霉素的生物合成与调控,2009-2011
(4) 国家自然基金——高选择性谷氨酸门控氯离子通道筛选体系研究与应用,2008-2010
(5) 国家自然科学基金——γ-氨基丁酸受体亲和筛选模型的构建和获得新配体方法的建立及应用,2006-2008
(6) 国家自然科学基金——基于与天门冬酰胺合成酶结合小分子信号的混合筛选及先导化合物的发现,2005-2005
(7) 国家自然科学基金——P450体外代谢除草剂模型的构建及作用,2003-2005
(8) 国家自然科学基金——P450催化除草剂代谢速率及羟基化位点与化合物结构的关系,2000-2002
(9) 国家自然科学基金——抗草甘膦EPSP合酶基因克隆及抗性机理,1997-1999
(10) 黑龙江省杰出青年基金,冰城链霉菌生物合成米尔贝霉素基因簇及调控基因克隆与高产代谢工程菌的构建,2008-2010
(11) “973”子项目,农药活性化合物及菌株筛选,2004-2008
(12) “龙江学者特聘教授”配套基金项目,2008-2010
(13) 省重点项目,多拉菌素工程菌的构建,2008-2010
(14) 哈尔滨市科委重点项目,多拉菌素高产优良的选育,2007-2009
(15) “973”子项目,农药活性化合物筛选及与靶分子的作用,2010-2014
 获奖成果
黑龙江省科技进步二等奖2
黑龙江省科技进步三等奖1
黑龙江省青年奖1项
大北农科技奖1项
 获得国家发明专利4
 论文著作
发表论文
1. Xiang-Jing Wang, Ming Wang, Ji-Dong Wang, Wen-Sheng Xiang. Isolation and Identification of Novel Macrocyclic Lactones from Streptomyces Avermitilis NEAU1069 with Acaricidal and Nematocidal Activity, Journal of Agricultural and Food Chemistry, (publishing)
2. Ming Wang, Xiao-Hu Yang, Ji-Dong Wang, Xiang-Jing Wang, Zheng-Jie Chen, Wen-Sheng Xiang. New β-Class Milbemycin Compound from Streptomyces avermitilis NEAU1069: Fermentation, Isolation and Structure Elucidation, J. Antibiotics, 2009, 62(10):587-591
3. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, Ji Zhang, Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties, J. Antibiotics, 2009, 62(9):501-505
4. Lu Shi-Xiang, Guo Yang-Hui, Wang Ya-Ping, Wang Xiang-Jing, Xiang Wen-Sheng. A novel synthesis of (R)-4-cyano-3-hydroxybutyric acid ethyl ester, Chinese Journal of Organic Chemistry, 2009,
5. Xiang-Jing Wang, Suo-Lian Guo, Wan-Qian Guo, Wen-Sheng Xiang. Role of nsdA in Negative Regulation of Antibiotic Production and Morphological Differentiation in Streptomyces bingchengensis, J. Antibiotics, 2009, 62(6):329-13
6. Xiang-Jing Wang, Xiao-Chong Wang, Wen-Sheng Xiang. Improvement of milbemycin-producing Streptomyces bingchenggensis by rational screening of ultraviolet- and chemically induced mutants, World Journal of Microbiology and Biotechnology, 2009, 25:1051-1056
7. Xiang-Jing Wang, Ji-Dong Wang, Wen-Sheng Xiang. Three new milbemycin derivatives from Streptomyces bingchenggensis, Journal of Asian Natural Products Research, 2009, 11 (7), 597-603
8. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, A novel macrolide compound from the Streptomyces bingchenggensis, Fermentation, Isolation, Structure Elucidation and Biological Properties, J. Antibiotics, 2009, 62(4):229-31
9. Hai Bo Sun, Guo Jun Zheng , Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang. Novel synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde: A key intermediate of Losartan, Chinese Chemical Letters, 20 (2009) 269-270
10. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Optimization of culture conditions for hydrogen production by Ethanoligenens harbinense B49 using response surface methodology. Bioresource Technology, 2009, 100 (3): 1192-6
11. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, New Seco-milbemycins from Streptomyces bingchenggensis: Fermentation, Isolation and Structure Elucidation, J.Antibiotics, 2008, 61 (1): 27-32
12. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, Two new components from Gnetum pendulum, J. of Asian Natural Products Research, 2008, 10: 1-5
13. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Biohydrogen production from ethanol-type fermentation of molasses in an expanded granular sludge bed (EGSB) reactor. Int J Hydrogen Energy, 2008, 33(19): 4981~4988
14. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Simultaneous biohydrogen production and starch wastewater treatment in an acidogenic expanded granular sludge bed reactor by mixed culture for long-term operation. Int J Hydrogen Energy, 2008, 33: 7397-7404
15. Nan-Qi Ren, Wan-Qian Guo, Xiang-Jing Wang, Wen-Sheng Xiang. Effects of different pretreatment methods on fermentation types and dominant bacteria for hydrogen production. Int J Hydrogen Energy, 2008, 33 (16): 4318~4324
16. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang. Two new milbemycins from Streptomyces bingchenggensis Fermentation, Isolation, Structure Elucidation and Biological properties, J. Antibiotics, 2007, 60 (6):351-356
17. iangjing Wang, Nanqi Ren, Wensheng Xiang. Influence of Gaseous End-products Inhibition and Nutrient Limitations on the Growth and Hydrogen Production by Hydrogen-producing Fermentative Bacterial B49, International Journal of hydrogen Energy, 2007(32):748-754
18. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang. Further New Milbemycin Antibiotics from Streptomyces bingchenggensis, J .Antibiotics, 2007, 60 (10): 608-613
19. Wensheng Xiang, Xiangjing Wang, Expression of a wheat cytochrome P450 monooxygenase cDNA in yeast catalyzes the metabolism of sulfonylurea herbicide. Pest. Biochem. Physio, 2006, 85(1):1-6
20. Xiang Wensheng, Wang Xiangjing, Purification of recombinant wheat cytochrome P450 monooxygenase expressed in yeast and its properties, Protein Expression and Purification, 2006(1):54-59
21. Wensheng Xiang, Xiangjing Wang, Expression of a wheat cytochrome P450 monooxygenase cDNA in yeast catalyzes the metabolism of sulfonylurea herbicide. Pest. Biochem. Physio, 2006, 85(1):1~6
著作、教材   
(1) “十一五”规划教材《仪器分析》,主编,哈尔滨工业大学出版社
(2) 《现代农业仪器分析应用技术》主编,东北林业大学出版社
(3) 《生物化学过程工程学》 副主编,科学出版社
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